Scaling up a proven technology!
THE BIO REVOLUTION
RESHAPING PRODUCTION RANGING FROM PHARMA & FOOD TO FASHION THROUGH THE INNOVATION OF ENGINEERED LIVING CELLS.
GENE EXPRESSION
Gene expression is a process by which information from a gene is used to synthesize a functional gene product, often a protein.
CODON-PROTEIN TRANSLATION
Each amino acid composing the protein chain can be expressed by an average of 3 different codons, i.e. there are about 3300 different mRNA sequences to express a specific 300 long amino acid protein.
THE BIO-REVOLUTION
IS TRANSFORMING SOCIETY FOR THE BETTER
Precision Fermentation:
DNA sequence insertion
into a host
Growth in bio-reactors
Separation and purification
Growth in bio-reactors
Molecular Farming:
DNA sequence insertion
into a host
Cultured tissues
Growth in plants
Harvest and purification
Final product
Moving from the conventional trial-and-error methods to data-driven engineering
RECODING TARGET GENES AT SCALE: OPTIMIZATION OF GENE EXPRESSION
Advanced computational models spanning every stage of the gene expression process
Swift optimization of target gene expression using AI and deep learning algorithms
EFFICIENT R&D: LOWER PRODUCTION COSTS & TIME-TO-MARKET
50-90%
LOWER COST OF FINAL PRODUCT
20-33%
FASTER TIME TO MARKET
SIGNIFICANT IMPROVEMENT IN THE PROTEIN PRODUCTION YIELD
3x-200x
PROTEIN PRODUCTION YIELD
PRODUCT
A CLOUD-BASED SECURED TOOL FOR GENE EXPRESSION OPTIMIZATION
Supplying optimized gene sequences tailored to your host organism
Backed by a scientific support team
Machine learning based iterative approach
Continuously improved data-driven models and algorithms
Supplying optimized gene sequences tailored to your host organism
Machine learning based iterative approach
Backed by a scientific support team
Continuously improved data-driven models and algorithms
MNDL BIO’S EXPERTISE IN GENE EXPRESSION OPTIMIZATION RESTS ON FOUR FUNDAMENTAL PILLARS
COMPREHENSIVE GENE EXPRESSION
Comprehending all
phases of the gene
expression across diverse hosts
MULTIDISCIPLINARY
TEAM
Collaboration of scientists from diverse fields (mathematics, physics, microbiology, engineering and computer science)
STRONG IP & VALIDATED TECHNOLOGY
Dozens of collaborations, 6 patent families, Hundreds of algorithms, 160 publications, 15 years of research at Professor Tuller's Lab
DISTINCTIVE
GENOMIC DATA
Proprietary and
public genomic big data.
THE FOUNDING TEAM
STEVE GRUN
PROF. TAMIR TULLER
ERAN MILLER
News & Publications
Read about our people, science and magic.
PAST CASE STUDIES-SUMMARY
| Result | Remarks | |
|---|---|---|
|
10x |
|
Hydrogen production in a microalga |
|
200x |
|
Mammalian gene in a diatom microalga |
|
3x |
|
Protein folding in Tobacco |
|
A few % |
A few % improve in growth rate |
S. cerevisiae titer & growth rate |
|
1.5x |
|
Antibody expression in S. cerevisiae |
|
10x |
10-fold increase in signal intensity |
Biosensors for explosives |
|
10x |
|
Density improvement of a virus |
|
10x |
|
Improving NDV titer in eggs (FFA) |
|
|
Significantly higher expression in
one cell one vs. the second one |
Tissue specific attenuation of an adenovirus gene only in HEK293 |
|
10x |
|
Improved bacteriophage M13 titer & improved also host titer |
|
5x |
|
Library of 500 PCV variants with different replication rates in animal cells PK 15 |
|
2.5x |
|
SARS-CoV-2 Vaccine in e. coli |
OUR PRODUCT
A cloud-based one-stop-shop tools for gene engineering and sequence optimization
One-stop-shop platform: Characterize and analyze data including storing, organizing and sharing biological data
End-to-end gene optimization: Gene sequences or synthesis, optimized for expression and genetic stability
Online support: By a scientific team
Iterative gene optimization: Increased performance through customer feedback
THE BIO-PROCESS DEVELOPMENT:
1. Research a protein of interest with the desired properties
2. Bioengineer a living organism to produce the protein of interest
3. Develop the production processes in large quantities
4. Isolate and purify the protein into a commercial product
THE FOUNDERS
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STEVE GRUN
PROF. TAMIR TULLER
ERAN MILLER
OUR TEAM
STEVE GRUN
- Over 10 Years of experience in General Management roles
- Over 25 years of experience in International Business Development, Marketing and Sales
- CEO at Yofix Probiotics (2018-2022)
- Division Managing Director at Chemovil Group (2015-2017)
- CEO at Carmit Candy Industries (2012-2015)
- M.Sc in Business Engineering
PROF. TAMIR TULLER
- Professor, head of Tel Aviv University's Lab of Computational Systems and Synthetic Biology
- 8 academic degrees incl. PhD Medical Sciences and PhD in Computer Science
- Author of over 160 peer-reviewed scientific journal articles
- Awards: Juludan Research Prize, Weizmann Institute of Science Koshland fellowship, Asi Shnidman foundation, Chaim Sheba Medical Center at Tel-Hashomer and many more
ERAN MILLER
- Technological Leadership: tech expert known for managing diverse projects globally and assessing startups for strategic investments, showcasing proficiency in R&D and cutting-edge technologies
- Global Program Manager: Head of Asia-Pacific Operations at Modu, led programs and global R&D teams, hands-on expertise in R&D and system integration
- MBA and BSc. in Electrical Engineering,
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We are doing
Amazingly Hover Effect
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Creative Agency.
Sketch & Design
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Research & Analyze
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Develop & Test
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Our Services
From our partners and friends...
Partnering with Tamir's expertise proved invaluable. His algorithms significantly enhanced our design of gene expression in microalgae, enabling us to achieve a substantial increase in biofuel production - a critical benchmark for our success.
Prof. Iftach Yacoby
Inefficient, costly gene expression optimization is a fundamental bottleneck in bioproduction today. MNDL Bio's data-driven approach, powered by Tamir Tuller's algorithms, promises a standardized, predictable solution with significant industry impact.
Dr. Or Rotem
